Warnings and precautions
Talk to your doctor, pharmacist or nurse before taking TAGRISSO if:
- You have a history of inflamed lungs (a condition called ‘interstitial lung disease’)
- You have ever had heart problems – your doctor may want keep a close eye on you.
- You have a history of eye problems.
If any of the above apply to you (or you are not sure), talk to your doctor, pharmacist, or nurse before taking this medicine.
Tell your doctor straight away while taking this medicine if:
- You have sudden difficulty in breathing with a cough or fever. See Serious side effects for more information.
- You have new or worsening shortness of breath, cough, tiredness, sudden weight gain or swelling of your feet, ankles or legs.
- You develop problems with your eyes such as eye pain, watery eyes, redness, blurred vision or sensitivity to light. See Serious side effects for more information.
Children and adolescents
TAGRISSO has not been studied in children or adolescents. Do not give this medicine to children or adolescents under the age of 18 years.
Other medicines and TAGRISSO
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes herbal medicines and medicines obtained without a prescription. This is because TAGRISSO can affect the way some other medicines work. Also, some other medicines can affect the way TAGRISSO works.
Tell your doctor before taking TAGRISSO if you are taking any of the following medicines:
The following medicines may reduce how well TAGRISSO works:
- Phenytoin, carbamazepine or phenobarbital – used for seizures or fits.
- Rifabutin or rifampicin – used for tuberculosis (TB).
- St. John’s Wort (Hypericum perforatum) – an herbal medicine used for depression.
TAGRISSO may increase side effects of these medicines:
- Warfarin – used for blood clots.
- Phenytoin and S-mephenytoin – used for seizures or fits.
- Alfentanil, fentanyl and other painkillers used for operations.
- Rosuvastatin – used to lower cholesterol.
- Oral hormonal contraceptive pill – used to prevent pregnancy.
- Bosentan – used for high blood pressure in the lungs.
- Efavirenz and etravirine – used to treat HIV infections/AIDS.
- Modafinil – used for sleep disorders.
If you are taking any of the medicines listed above, tell your doctor before taking TAGRISSO.
Your doctor will discuss appropriate treatment options with you.
Pregnancy – information for women
If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine. If you do become pregnant during treatment, tell your doctor straight away. Your doctor will decide with you whether you should carry on taking TAGRISSO. You should not become pregnant while taking this medicine. If you are able to become pregnant, you must use effective contraception. See ‘Contraception – information for women and men’ below. If you plan to become pregnant after taking the last dose of this medicine, ask your doctor for advice. This is because some medicine may remain in your body.
Pregnancy – information for men
If your female partner becomes pregnant while you are taking this medicine, tell your doctor straight away.
Contraception – information for women and men
Women must use effective contraception during treatment.
Discuss with your doctor the most appropriate methods of contraception. TAGRISSO may pass into semen. Therefore, it is important that men also use effective contraception.
You must also do this after completing treatment with TAGRISSO:
Women – keep using contraception for 2 months after your last dose of TAGRISSO.
Men – keep using contraception for 4 months after your last dose of TAGRISSO.
Breast-feeding
Do not breast-feed while taking this medicine. This is because it is not known if there is a risk to your baby.
Driving and using machines
TAGRISSO has no or no marked influence on the ability to drive and use machines.